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7 of 69 compounds
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A seven-residue fragment built in Moscow, sold in Russian pharmacies as nasal drops, and listed among that country's Vital and Essential Medicines. The Western file on it is nearly empty. Both facts are true at once.

Delta Sleep-Inducing Peptide. Boldest name in the catalogue by a distance, and the human file behind it is about five studies, all from between 1981 and 1992.

Semax's labmate from the same Moscow institute, built off an immune peptide called tuftsin. Registered in Russia, studied almost entirely without placebo controls, unknown to Western regulators.

The first peptide hormone anyone ever built by hand instead of grinding out of a gland. That synthesis won the 1955 Nobel, and two residues separate it from vasopressin, a completely different hormone.

A fragment derived from CNTF wearing an adamantane cage so it can cross into the brain. Orally active in mice, studied in dementia models, and no human has ever taken it in a trial.

A peptide preparation made from pig brain, used in clinics across half the world. A 2023 Cochrane review found no mortality benefit and a 2.39 relative risk of serious adverse events. We are leading with that on purpose.

Seven residues that shut a potassium channel called TREK-1. One laboratory, one paper, and a number so striking that the right response is to wait for somebody else to see it too.
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