Gonadorelin Peptide
GnRH itself, the exact ten-residue pulse your hypothalamus sends. Its discovery won the 1977 Nobel. Every human product of it in Canada is cancelled; the marketed DINs are for cattle.
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For research use only. Not for human or veterinary use.
What Gonadorelin Peptide is
The plain-language version, first.
The actual hormone, unmodified, Nobel citation and all.
Gonadorelin is a synthetic decapeptide identical to endogenous gonadotropin releasing hormone, sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, with molecular formula C55H75N17O13, molecular weight 1182.3 and CAS number 33515-09-2. No human gonadorelin product is currently marketed in Canada or the United States, as the FDA registrations Factrel and Lutrepulse are discontinued and all Canadian human DINs are cancelled or dormant, leaving only veterinary preparations on the market.
This is not an analogue of anything. Gonadorelin is GnRH, the genuine ten-residue hormone, sequence-identical to what your hypothalamus releases.
Characterising it won the 1977 Nobel Prize. This molecule is a chapter heading in endocrinology.
It sits one step below kisspeptin in the reproductive chain of command: it carries the order from brain to pituitary, in pulses, roughly every ninety minutes.
And here is the strangest fact on this page: check the Canadian drug registry and every human gonadorelin product is cancelled.
The marketed DINs that remain are veterinary. In this country, the molecule that won a Nobel for human endocrinology is officially cattle medicine.
gonadorelin peptide and GnRH signalling
Mechanism studied, not outcome promised.
GnRHR is a GPCR sitting on pituitary gonadotroph cells. Gq, then phospholipase C, then calcium, then the cell releases its stored LH and FSH. Short chain, well mapped, no mystery left in it.
Belchetz and colleagues, Science 1978, in hypothalamically lesioned rhesus monkeys. Hourly pulses reestablished gonadotropin secretion. Continuous infusion failed to sustain it. The abstract credits the pattern of delivery rather than the amounts.
Gonadorelin clears fast because your body built it to. That's a feature for pulsatile work and a nuisance for everything else, and it's precisely why the long acting analogues got invented.
The pulse is the message. This axis reads rhythm, not volume.
This axis runs on the most famous rhythm lesson in endocrinology, and it is worth learning properly.
Pulsed GnRH, arriving every hour or two, keeps the pituitary releasing its hormones normally. Continuous GnRH exposure does the opposite: the receptors downregulate and the axis shuts off.
Same molecule. Same receptor. Opposite outcomes, decided entirely by timing.
That paradox is not a footnote, it is clinically exploited on purpose by the long-acting agonists, which suppress the axis by refusing to pulse.
Here's the honest part, and it writes itself.
A signal whose meaning inverts with its rhythm is a signal that punishes crude use. The pulse is not a detail of the mechanism. It is the mechanism.
The research so far for Gonadorelin Peptide
Where the evidence is thin, we say so.
The 1977 Nobel Prize in Physiology or Medicine for the discovery of the hypothalamic releasing hormones. A confirmed decapeptide sequence identical to endogenous GnRH, with PubChem and the FDA Factrel label agreeing on C55H75N17O13 and 1182.3. Decades of literature on the GnRH stimulation test and on pulsatile pump therapy for hypothalamic amenorrhoea.
A marketed human product. Factrel and Lutrepulse are discontinued at FDA, every Canadian human DIN is cancelled or dormant, and the only gonadorelin DINs Health Canada shows as marketed today are veterinary. There's no exemption hiding in that gap either, since WADA names gonadorelin in S2.2.1 no matter what's on a shelf.
Gonadorelin occupies an unusual regulatory position, in that the endogenous ligand is commercially extinct in North American human medicine while its synthetic analogues remain widely marketed. FDA lists Factrel, NDA 018123, and Lutrepulse, NDA 019687, as discontinued. Health Canada shows every human gonadorelin DIN cancelled or dormant, including 00368385, 02042096 and 02041820 for Factrel, 02046202 and 02046210 for Lutrepulse, the latter cancelled in December 2024, and Relisorm cancelled in 2019. The only gonadorelin DINs currently marketed in Canada are veterinary preparations used in bovine reproductive management. The displacement is mechanistic as much as commercial. Native GnRH has a short circulating half life and therefore reproduces physiological pulsatility, which requires pump hardware to exploit clinically, whereas substituted analogues achieve sustained receptor occupancy from a depot injection and produce suppression on a schedule a clinic can actually run. Gonadorelin remains explicitly named in section S2.2.1 of the WADA Prohibited List regardless of its marketing status.
A foundational molecule whose Canadian market is, literally, livestock.
The foundational science is as solid as anything on this shelf: Nobel-cited, receptor mapped, the pulse-versus-continuous paradox replicated for decades.
Human clinical use existed historically, including pulsatile pumps for specific fertility conditions, faithful to the rhythm principle.
The modern reality: human products cancelled in Canada, remaining registrations veterinary, and clinical practice moved to engineered analogues.
So what is sold as research material is a molecule of genuine historical and physiological importance whose human pharmaceutical era has simply ended here.
A Nobel molecule in regulatory retirement. The biology stayed important. The product moved on.
Gonadorelin · lyophilised powder · sealed vial · Canadian stock, ships from BC
Gonadorelin Peptide specs
The chemistry, exactly as released.
Who studies Gonadorelin Peptide
Who tends to order this one, and why.
A research compound does not have one audience. It has a handful of rooms where the same question keeps coming up, and the question is a different question in each of them.
Reproductive endocrinology labs
Bench work on the hypothalamic pituitary gonadal axis, where the native ligand is the honest starting point rather than an analogue with its own kinetics layered on top.
Pulsatility and desensitisation models
Anybody reproducing or extending the Belchetz result, where the variable under test is the pattern of receptor exposure over time rather than the substance itself.
GnRH receptor pharmacology
Binding and Gq signalling studies at GnRHR that need the endogenous decapeptide as the comparator against triptorelin, leuprolide or any of the other substituted analogues.
Analytical and reference use
Method development that calls for a decapeptide with a published formula, a settled mass and a sequence that two independent sources agree on down to the terminal amide.
Sold for laboratory research only. This is not guidance for personal use, and nothing here is a recommendation.
Gonadorelin Peptide backstory
How it got here.
Two labs spent the sixties chasing the same ghost. Everybody was convinced the hypothalamus talked to the pituitary chemically, and nobody could catch the messenger, because catching it meant working through a mountain of tissue to end up with a few milligrams of something that acts at concentrations you can barely measure.
Roger Guillemin and Andrew Schally raced each other to it, and not warmly. When the structure finally landed in 1971 it was ten residues long, which has to have felt anticlimactic for something that ate a decade of two careers.
The 1977 Nobel Prize in Physiology or Medicine went to the pair of them, sharing it with Rosalyn Yalow, whose radioimmunoassay is the technique that made hunting these things possible at all. The punchline shows up fifty years later.
The molecule they bled for has no human product on the market anywhere in North America, and the brand name Factrel is now printed on a bottle in a cattle vet's fridge.
- 1
1971, ten residues
After a decade of two rival labs grinding through hypothalamic tissue, the structure of GnRH lands, and the messenger everybody hunted turns out to be a decapeptide.
- 2
1977, Stockholm
Guillemin and Schally share the Nobel Prize in Physiology or Medicine, alongside Rosalyn Yalow for the radioimmunoassay that made the whole hunt technically possible.
- 3
2024, the last cancellation
Health Canada cancels DIN 02046210 in December, closing the book on human gonadorelin in Canada. Factrel is still stocked, just in the veterinary fridge.
Buying Gonadorelin Peptide in Canada
What ships, how fast, and the paperwork.
The hard part of buying research material is almost never the compound. It is the logistics. What leaves the building, how fast it moves, and what is in the box beside the vial. Here is ours, plainly.
There's no human product to compare it to
Every human gonadorelin DIN in Canada is cancelled or dormant, so there's nothing on the market to hold this up against. It also isn't the veterinary product. It's a research reagent for laboratory use, sold for that and nothing else.
Named on the WADA list
Gonadorelin appears by name in section S2.2.1 of the Prohibited List. Discontinued doesn't mean unrestricted. The list tracks substances, not marketing status, and it doesn't care that the human registrations went dark.
Ships domestic
Stock sits in British Columbia and orders leave from there, so nothing gets stuck at a border waiting on somebody's mood. Lyophilised powder in a sealed vial.
Stuff people ask about Gonadorelin Peptide
If your question is not here, email us. Real human answers.
The synthetic version of GnRH, the hormone your hypothalamus uses to tell your pituitary to release LH and FSH. Ten amino acids, pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, formula C55H75N17O13, molecular weight 1182.3, CAS 33515-09-2. It isn't an analogue of anything. The sequence is identical to what your own brain makes, which is why it behaves like the real signal does.
Not for people. Factrel and Lutrepulse are both discontinued at FDA, and Health Canada shows every human gonadorelin DIN as cancelled or dormant, with the last cancellation landing in December 2024. The only gonadorelin DINs marketed in Canada now are veterinary ones for cattle fertility work. That's a commercial outcome rather than a safety recall.
One residue, and a completely opposite job. Triptorelin is the same decapeptide with D-tryptophan swapped in at position six, which makes it resistant to breakdown and long acting. Native gonadorelin clears fast, so it reads as a pulse. Sustained occupancy desensitises the receptor instead of stimulating it, so one of them starts the axis and the other shuts it down.
Yes, named explicitly in section S2.2.1. Worth knowing, because people assume a discontinued product quietly falls off the radar. It doesn't. The Prohibited List tracks substances and not marketing status, and gonadorelin's entry sits right next to triptorelin's. If you're subject to testing, treat it that way regardless of what a pharmacy stocks.
Narrow indications, mostly. The human uses were a diagnostic challenge test and pulsatile pump therapy for hypothalamic amenorrhoea, and the pump route needed hardware most clinics had no appetite to run. Long acting analogues covered the suppression side of the market from a single depot injection instead. Cattle fertility is a volume business, which is where the brand name ended up living.
Lyophilised gonadorelin powder in a sealed vial, sold as a research chemical for laboratory use only. Not for human consumption, not for veterinary use, and not a substitute for any medicine, seeing as Canada no longer has a marketed human one. Stock sits in British Columbia and orders go out domestically from there.
Good pairing options with Gonadorelin Peptide
What researchers stack alongside it.
Pairing is where research gets ahead of itself. These are the compounds researchers put in the same order as Gonadorelin Peptide, which is a statement about ordering habits, not about evidence. Two things in one cart have not been studied together unless somebody studied them together.
Not a molecule. FSH and LH activity extracted from postmenopausal urine and standardised in international units. Still marketed in Canada in 2026, which makes it the rare extract with live approvals.
The unprocessed precursor, all 344 residues with the signal peptide still attached. The protein your body actually secretes is a different animal: 315 residues and 36 cysteines folded just so.
Order Gonadorelin Peptide right now
One last look before you decide.
Freeze-dried, COA on the page, ships cold
If you are researching Gonadorelin Peptide and you want a source you do not have to second-guess, start with the paperwork on this page. For research use only.
Not for human consumption. Not approved by Health Canada or any other regulatory body.
Page last updated August 19, 2026
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