Gonadorelin Peptide
A Nobel Prize molecule with no human product left on the market.
Choose your pack
For research use only. Not for human or veterinary use.
What Gonadorelin is
The plain-language version, first.
The actual hormone, unmodified, Nobel citation and all.
Gonadorelin is a synthetic decapeptide identical to endogenous gonadotropin releasing hormone, sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, with molecular formula C55H75N17O13, molecular weight 1182.3 and CAS number 33515-09-2. No human gonadorelin product is currently marketed in Canada or the United States, as the FDA registrations Factrel and Lutrepulse are discontinued and all Canadian human DINs are cancelled or dormant, leaving only veterinary preparations on the market.
This is not an analogue of anything. Gonadorelin is GnRH, the genuine ten-residue hormone, sequence-identical to what your hypothalamus releases.
Characterising it won the 1977 Nobel Prize. This molecule is a chapter heading in endocrinology.
It sits one step below kisspeptin in the reproductive chain of command: it carries the order from brain to pituitary, in pulses, roughly every ninety minutes.
And here is the strangest fact on this page: check the Canadian drug registry and every human gonadorelin product is cancelled.
The marketed DINs that remain are veterinary. In this country, the molecule that won a Nobel for human endocrinology is officially cattle medicine.
gonadorelin peptide and GnRH signalling
Mechanism studied, not outcome promised.
The pulse is the message. This axis reads rhythm, not volume.
This axis runs on the most famous rhythm lesson in endocrinology, and it is worth learning properly.
Pulsed GnRH, arriving every hour or two, keeps the pituitary releasing its hormones normally. Continuous GnRH exposure does the opposite: the receptors downregulate and the axis shuts off.
Same molecule. Same receptor. Opposite outcomes, decided entirely by timing.
That paradox is not a footnote, it is clinically exploited on purpose by the long-acting agonists, which suppress the axis by refusing to pulse.
Here's the honest part, and it writes itself.
A signal whose meaning inverts with its rhythm is a signal that punishes crude use. The pulse is not a detail of the mechanism. It is the mechanism.
The research so far for Gonadorelin
Where the evidence is thin, we say so.
A foundational molecule whose Canadian market is, literally, livestock.
The foundational science is as solid as anything on this shelf: Nobel-cited, receptor mapped, the pulse-versus-continuous paradox replicated for decades.
Human clinical use existed historically, including pulsatile pumps for specific fertility conditions, faithful to the rhythm principle.
The modern reality: human products cancelled in Canada, remaining registrations veterinary, and clinical practice moved to engineered analogues.
So what is sold as research material is a molecule of genuine historical and physiological importance whose human pharmaceutical era has simply ended here.
A Nobel molecule in regulatory retirement. The biology stayed important. The product moved on.
Gonadorelin · lyophilised powder · sealed vial · Canadian stock, ships from BC
Gonadorelin specs
The chemistry, exactly as released.
Who studies Gonadorelin
Who tends to order this one, and why.
- 1
Reproductive endocrinology labs
Bench work on the hypothalamic pituitary gonadal axis, where the native ligand is the honest starting point rather than an analogue with its own kinetics layered on top.
- 2
Pulsatility and desensitisation models
Anybody reproducing or extending the Belchetz result, where the variable under test is the pattern of receptor exposure over time rather than the substance itself.
- 3
GnRH receptor pharmacology
Binding and Gq signalling studies at GnRHR that need the endogenous decapeptide as the comparator against triptorelin, leuprolide or any of the other substituted analogues.
- 4
Analytical and reference use
Method development that calls for a decapeptide with a published formula, a settled mass and a sequence that two independent sources agree on down to the terminal amide.
Sold for laboratory research only. This is not guidance for personal use, and nothing here is a recommendation.
Gonadorelin backstory
How it got here.
Two labs spent the sixties chasing the same ghost. Everybody was convinced the hypothalamus talked to the pituitary chemically, and nobody could catch the messenger, because catching it meant working through a mountain of tissue to end up with a few milligrams of something that acts at concentrations you can barely measure.
Roger Guillemin and Andrew Schally raced each other to it, and not warmly. When the structure finally landed in 1971 it was ten residues long, which has to have felt anticlimactic for something that ate a decade of two careers. The 1977 Nobel Prize in Physiology or Medicine went to the pair of them, sharing it with Rosalyn Yalow, whose radioimmunoassay is the technique that made hunting these things possible at all.
The punchline shows up fifty years later. The molecule they bled for has no human product on the market anywhere in North America, and the brand name Factrel is now printed on a bottle in a cattle vet's fridge.
- 1
1971, ten residues
After a decade of two rival labs grinding through hypothalamic tissue, the structure of GnRH lands, and the messenger everybody hunted turns out to be a decapeptide.
- 2
1977, Stockholm
Guillemin and Schally share the Nobel Prize in Physiology or Medicine, alongside Rosalyn Yalow for the radioimmunoassay that made the whole hunt technically possible.
- 3
2024, the last cancellation
Health Canada cancels DIN 02046210 in December, closing the book on human gonadorelin in Canada. Factrel is still stocked, just in the veterinary fridge.
Buying Gonadorelin in Canada
What ships, how fast, and the paperwork.
There's no human product to compare it to. Every human gonadorelin DIN in Canada is cancelled or dormant, so there's nothing on the market to hold this up against. It also isn't the veterinary product. It's a research reagent for laboratory use, sold for that and nothing else.
Named on the WADA list. Gonadorelin appears by name in section S2.2.1 of the Prohibited List. Discontinued doesn't mean unrestricted. The list tracks substances, not marketing status, and it doesn't care that the human registrations went dark.
Ships domestic. Stock sits in British Columbia and orders leave from there, so nothing gets stuck at a border waiting on somebody's mood. Lyophilised powder in a sealed vial.
Common questions
5 answers, none of them dodges.
What is gonadorelin?
The synthetic version of GnRH, the hormone your hypothalamus uses to tell your pituitary to release LH and FSH. Ten amino acids, pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, formula C55H75N17O13, molecular weight 1182.3, CAS 33515-09-2. It isn't an analogue of anything. The sequence is identical to what your own brain makes, which is why it behaves like the real signal does.
Can you still get gonadorelin as a medicine in Canada?
Not for people. Factrel and Lutrepulse are both discontinued at FDA, and Health Canada shows every human gonadorelin DIN as cancelled or dormant, with the last cancellation landing in December 2024. The only gonadorelin DINs marketed in Canada now are veterinary ones for cattle fertility work. That's a commercial outcome rather than a safety recall.
What's the difference between gonadorelin and triptorelin?
One residue, and a completely opposite job. Triptorelin is the same decapeptide with D-tryptophan swapped in at position six, which makes it resistant to breakdown and long acting. Native gonadorelin clears fast, so it reads as a pulse. Sustained occupancy desensitises the receptor instead of stimulating it, so one of them starts the axis and the other shuts it down.
Is gonadorelin on the WADA Prohibited List?
Yes, named explicitly in section S2.2.1. Worth knowing, because people assume a discontinued product quietly falls off the radar. It doesn't. The Prohibited List tracks substances and not marketing status, and gonadorelin's entry sits right next to triptorelin's. If you're subject to testing, treat it that way regardless of what a pharmacy stocks.
Why did the human products disappear?
Narrow indications, mostly. The human uses were a diagnostic challenge test and pulsatile pump therapy for hypothalamic amenorrhoea, and the pump route needed hardware most clinics had no appetite to run. Long acting analogues covered the suppression side of the market from a single depot injection instead. Cattle fertility is a volume business, which is where the brand name ended up living.
Good pairing options with Gonadorelin
What researchers stack alongside it.
Pairing is where research gets ahead of itself. These are the compounds researchers put in the same order as Gonadorelin Peptide, which is a statement about ordering habits, not about evidence. Two things in one cart have not been studied together unless somebody studied them together.
In 1950s Rome one clinician made a claim about this hormone that the evidence never supported. Seventy years later the claim is still in circulation and still unsupported.
Not a molecule. FSH and LH activity extracted from postmenopausal urine and standardised in international units. Still marketed in Canada in 2026, which makes it the rare extract with live approvals.
It is water. We know. But it is the one bottle on this shelf where the boring ingredient is the entire product, and getting it wrong ruins everything else you bought.
Order Gonadorelin right now
One last look before you decide.
Freeze-dried, ships cold from Canada
You've got the whole file now, the thin parts included. Nothing above pretended otherwise. If that's the kind of source you were after, Gonadorelin is right here.
Not for human consumption. Not approved by Health Canada or any other regulatory body.
Page last updated October 4, 2026
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